|
KMID : 0604220060130030073
|
|
Korean Journal Investigative Dermatology
2006 Volume.13 No. 3 p.73 ~ p.82
|
|
|
Effects of Coapplication of Neuropeptides on the Human Hair Growth in Vitro
|
|
Pi Long-Quan
Oh Tak-Heon
Lee Sang-Hoon
Lee Won-Soo
|
|
|
Abstract
|
|
|
|
The peripheral nervous system has an important role in the hair growth, which is mediated by neuropeptides. Also, the hair growth-related factors are important in the hair growth. The aim of this study was to analyze the effect of combined administration of substance P(SP) and calcitonin gene-related peptide(CGRP) on human hair growth and investigate the relationship between the neuropeptides and expression of various hair growth-related factors in the hair follicle. The result was that the combined administration of SP and CGRP had decreased the follicle growth rate from the 6th day on, compared to the control group, and the number of catagen phase follicles had rapidly increased, which was statistically significant. In hair follicles, the expression of IL-1 increased. In dermal papilla(DP) cells, the expression of IL-1 increased. The proliferation of cells of combined administration group in every DP cells and ORS cells declined to some extent. The combined administration of SP and CGRP has a negative effect on the hair growth, especially in shortering the duration of the anagen phase of the hair growth cycle, and these effects of neuropeptides probably occur at least in part via up-regulation of the recognized hair growth-inhibitory factor IL-1.
|
|
|
KEYWORD
|
|
|
Neuropeptide, Substance P(SP), Calcitonin gene-related peptide(CGRP), Hair growth- related factor’Human hair follicle
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|